Vol. 7, Issue 1, Part A (2025)

Background and aim: The cardiovascular system has vitamin D (Vit.D) receptors, and epidemiological investigations have documented a correlation between Vit.D status and the likelihood of developing Coronary artery disease (CAD).In this study, we aimed to detect the correlation between vitamin D deficiency and the severity of coronary artery (CAD) disease in postmenopausal women with chronic coronary syndrome using the SYNTAX score as a severity parameter of coronary artery disease. 
Study design: An observational, cross-sectional study. 
Place and duration of study: This study was conducted at the cardiology department at Benha University Hospital and the cardiology department at Misr International Hospital. 
Methodology: This study included 200 female patients with chronic coronary syndrome (CCS). Patients were divided into two groups: The first group consisted of female patients with CCS and normal Vit D level (31–100 ng/mL). The second group included female patients with CCS and Vit.D deficiency who were further subdivided according to the Vit.D deficiency level into (Vit. D severe deficiency group with Vit D level <10 ng/mL and Vit D insufficiency group with Vit. D level ranging from (10–30 ng/mL). A comparison of the SYNTAX score of the three groups was used to measure CAD severity. 
Results: There was a significant negative correlation between Vitamin D insufficiency, serum creatinine (r = -0.183, P = 0.025), and total cholesterol (r = -0.528, p<0.001), TG (r = -0.371, p<0.001). There was a significant positive correlation between Vit D insufficiency and HDL (r = 0.188, P = 0.021). SYNTAX score was significantly higher in both Vit D insufficiency and Vit D severe deficiency groups compared to the control group (p<0.001). 
Conclusion: In female patients with chronic coronary syndrome, vitamin D, both insufficiency and severe deficiency, was not only associated with increased levels of total cholesterol, triglycerides, and LDL levels but was also associated with increased severity of CAD represented by higher SYNTAX score in these patients.