Vol. 7, Issue 1, Part A (2025)

Background: STEMI remains a major contributor to morbidity and mortality despite advancements in primary percutaneous coronary intervention (PPCI). Central arterial pressure (CAP), measured during PPCI, has emerged as a potential predictor of MACEs during hospitalization. This investigation aims to evaluate prognostic value of CAP parameters in STEMI patients undergoing PPCI.

Methods: This prospective observational study included 115 STEMI patients undergoing PPCI, categorized into non-MACEs (no events) and MACEs (≥1 event). Intraoperative central systolic pressure (CSP), central diastolic pressure (CDP), central pulse pressure (CPP), and central mean pressure (CMP) were recorded, alongside clinical, laboratory, echocardiographic, and angiographic data. Multivariate logistic regression and ROC analysis assessed their predictive value.

Results: MACEs occurred in 29.6% of patients. CSP ≥137.5 mmHg (OR = 1.19, P = 0.02) and <102 mmHg (OR = 1.92, P< 0.001) were significant predictors. CDP<61 mmHg (OR = 1.37, P = 0.004), CPP<29 mmHg (OR = 2.19, P = 0.003), and CMP<76 mmHg (OR = 4.13, P< 0.001) were also independently associated with MACE. ROC analysis showed that CPP ≥39.5 mmHg had the highest predictive accuracy (AUC = 0.703, P< 0.001).

Conclusion: CAP parameters measured during PPCI are significant predictors of in-hospital MACE in STEMI patients. Incorporating CAP into risk stratification models may enhance early identification of high-risk patients, improving clinical decision-making.