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International Journal of Cardiology Sciences

Vol. 7, Issue 1, Part A (2025)

Left ventricle global longitudinal strain is a predictor of major adverse cardiovascular outcomes in patients with left ventricular non-compaction: Cardiac magnetic resonance feature tracking study

Author(s):

Ahmed Elshall, Seham Bader, Mai Salama, Mahmoud Elamrosi, Randa Abdelmageed, Mohamed Elzoghby, Mahmoud Shaaban, Wesam Elmozy, Mahmoud Salah, Rehab Elnagar and Soha Romeih

Abstract:

Background: Cardiac magnetic resonance Imaging (CMR) is used to coin the diagnosis of LVNC, as it provides additional morphologic and prognostic information that overcome the data obtained by echocardiography. LVNC patients may develop a wide range of major adverse cardiovascular events (MACE). The assessment of myocardial deformation has been proven to be more sensitive than ejection fraction (EF) in the detection of subclinical ventricular dysfunction. Ventricular myocardial deformation can be accurately evaluated via strain analysis using CMR feature tracking (FT). However, prognostic role of ventricular myocardial deformation in LVNC patients is not evaluated yet. The purpose of our study was to assess the prognostic role of ventricular myocardial deformation assessed by CMR-FT to predict MACE in LVNC patients.

Results: Fifty patients diagnosed with LVNC were subsequently categorized into two groups according to the incidence of MACE during the follow-up period. Group I comprised 20 patients who experienced MACE, while Group II consisted of 30 patients who did not experience MACE. Group I had a significantly higher LV volumes, lower LV EF, and higher incidence of myocardial fibrosis compared to Group II. Group I has a statistically significantly lower LV strain parameters than group II. Myocardial fibrosis, lower LV-EF, lower LV GLS, GCS, were univariate predictors of MACE. LV-GRS was not correlated with MACE. In multivariate analysis LV GLS was a strong predictor for MACE.

Conclusion: In patients with LVNC, LV GLS measured by CMR-FT technique were a strong predictor for MACE in LVNC patients.

Pages: 20-28  |  32 Views  10 Downloads


International Journal of Cardiology Sciences
How to cite this article:
Ahmed Elshall, Seham Bader, Mai Salama, Mahmoud Elamrosi, Randa Abdelmageed, Mohamed Elzoghby, Mahmoud Shaaban, Wesam Elmozy, Mahmoud Salah, Rehab Elnagar and Soha Romeih. Left ventricle global longitudinal strain is a predictor of major adverse cardiovascular outcomes in patients with left ventricular non-compaction: Cardiac magnetic resonance feature tracking study. Int. J. Cardiol. Sci. 2025;7(1):20-28. DOI: 10.33545/26649020.2025.v7.i1a.91