Contact: +91-9711224068
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
International Journal of Cardiology Sciences

Vol. 6, Issue 2, Part B (2024)

Positively remodeled coronary artery lesion detected by multislice CT as a predictor of future cardiovascular events

Author(s):

Basant Zahid, Elsayed Abdal Khalek, Ibrahim Mostafa Helmy, Ahmed Sabri Youssif Abdelaziz and Ali Ibrahim Atya

Abstract:

Background: Positively remodeled coronary artery lesions, despite causing non-significant arterial stenosis, have been implicated in adverse cardiovascular events. This study aims to identify the morphological characteristics of positively remodeled coronary lesions detected by multi-slice computed tomography (MSCT) coronary angiography and evaluate their predictive value for cardiovascular events over a 90-day follow-up.
Methods: This prospective cohort study included 50 patients undergoing MSCT coronary angiography at the National Heart Institute. Patients with a single-vessel disease exhibiting positive arterial remodeling with non-significant stenosis were selected. Clinical assessments, including demographic data, cardiovascular risk factors, and MSCT findings, were collected. Follow-up was conducted at 90 days to record adverse cardiovascular events
Results: Among the 50 patients, 20 (40%) developed cardiovascular events within 90 days. Significant predictors of future events included dyslipidemia (p = 0.012), diabetes mellitus (p = 0.001), LDL levels (p< 0.001), total cholesterol (p = 0.004), HDL levels (p = 0.048), and the remodeling index (p< 0.001). CT measurements revealed that higher wall/lumen area percentage (p< 0.001), plaque burden percentage (p< 0.001), and high-attenuation plaque area (p< 0.001) were significant predictors. Wall/lumen area percentage and plaque burden percentage showed the highest predictive performance, with 100% sensitivity and specificity.
Conclusions: Positively remodeled coronary lesions, particularly those with higher wall/lumen area and plaque burden, are strong predictors of future cardiovascular events. Comprehensive analysis of plaque characteristics and arterial measurements can enhance risk stratification, aiding in the prevention and management of cardiovascular disease.
 

Pages: 149-155  |  254 Views  74 Downloads


International Journal of Cardiology Sciences
How to cite this article:
Basant Zahid, Elsayed Abdal Khalek, Ibrahim Mostafa Helmy, Ahmed Sabri Youssif Abdelaziz and Ali Ibrahim Atya. Positively remodeled coronary artery lesion detected by multislice CT as a predictor of future cardiovascular events. Int. J. Cardiol. Sci. 2024;6(2):149-155. DOI: 10.33545/26649020.2024.v6.i2b.77