Vol. 6, Issue 2, Part B (2024)

Background: Cardiovascular diseases are among the most widespread diseases around the world that lead to death. Studying inflammatory and cardiac biomarkers reveals new insights into reducing the risk of infection and helping in early diagnosis.
Aims of the study: Evaluating the relationship between cardiac and inflammatory indicators and their relationship to the severity of cardiovascular disease. 
Methodology: A case-control study included 50 samples from patients with heart disease diagnosed according to the inclusion criteria and 25 samples from healthy controls. The study was conducted with the approval of the Ethics Committee at the College of Medicine at Al-Nahrain University at Al-Nasiriyah Heart Hospital in Thi-Qar, Iraq, between 1/3/2022 and 1/3/2023. Patients' data were recorded, 5 ml of blood was drawn, and then the serum was separated and stored at -20 °C. Troponin, CRP, CKMP, and BNP levels were measured using an ELISA device. 
Result: The study found that there were no statistically important changes in age or body mass index between the control group and the patient group. The amounts of CRP, troponin, BNP, and CK-MB were much higher in people with heart disease compared to healthy controls. The results showed that there were positive links between age and CK-MB and BNP. However, there were no statistically significant links between age and CRP or troponin. An interesting thing about CRP is that it correlated positively with CK-MB but not with troponin or BNP. 
Conclusions: The study showed that CRP, troponin, BNP, and CK-MB levels were significantly higher in heart patients compared to healthy controls, reflecting inflammation and myocardial damage. BNP and CK-MB levels were also associated with increasing age. These results support the importance of monitoring these biomarkers for heart disease diagnosis and early medical intervention.