Vol. 6, Issue 2, Part A (2024)

Background: As a straightforward laboratory test, serum uric acid (SUA) measurement could be easily carried out at low cost. Previously, it has been suggested as an independent CIN predictor among those having ST-elevation myocardial infarction (STEMI) who underwent treatment with primary percutaneous coronary intervention (PCI). This work was designed to investigate whether SUA levels could be a good predictor for CIN occurrence following PCI.

Methods: Our team designed a prospective observational study, involving 100 cases with ages ranging between 18 to 80 years, both genders, who underwent elective PCI procedure. All participants were equally categorized into two groups based on SUA level when admitted: Group A: SUA ≤ 7.0 mg/dl while group B: SUA above 7.0 mg/dl.

Results: Serum urea and SUA, baseline Serum creatinine level and serum creatinine clearance showed insignificant variance among both groups (CIN developed and not developed group). Nevertheless, a significant variance was noted in creatinine levels in addition to creatinine clearance at 24 hours, 48 hours and 72 hours among both groups. Angiographic and procedural characteristic (Number of vessels, Number of stents, Procedural duration and contrast volume exhibited insignificantl variance among both groups. Medications along with the CIN incidence were insignificantly varied among both groups.

Conclusion: The CIN frequency of occurrence exhibited no variation among cases having normal and elevated uric acid, which is probably due to the presence of cases with reduced risk as well as interventions with sufficient preventive measures. Nevertheless, hyperuricemia was correlated with deteriorated kidney function both prior to and following the procedure.