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International Journal of Cardiology Sciences

Vol. 5, Issue 2, Part A (2023)

Impact of the time factor on the development of in-hospital heart failure in patients presenting with anterior ST-segment elevation myocardial infarction undergoing primary PCI

Author(s):

Eman Helmy Eldesokey, Medhat Mohamed Ashmawy, Mohamed Naseem Hussien, Amany Mohammed AL-Laithy

Abstract:

Background: The incidence rate of newly diagnosed instances of heart failure subsequent to an acute ST-elevation myocardial infarction (STEMI) has a range of variability spanning from 10% to 45%. The aim of this study is to assess the association between the duration of delay in patients diagnosed with anterior STEMI who have primary percutaneous coronary intervention, and the occurrence of heart failure during their hospitalization.
Methods: This prospective study was carried out on 100 consecutive patients with clinical criteria of first anterior ST- elevation myocardial infarction (STEMI). Patients were subdivided into two groups: Group 1: treated by primary PCI without development of heart failure. Group 2: treated by primary PCI with development of heart failure. 
Results: In univariate regression analysis, older age, HTN, DM, symptoms duration, number of diseased vessels, TIMI flow, serum creatinine and LV EF were correlated with AHF. In the multivariate regression analysis, using model adjusted for aforementioned parameters, LV EF and symptoms duration independently predicted AHF. According to the simulation results, the cut off value to discriminate AHF from Non-AHF was (>8 hours) with 100% sensitivity, 44.29% specificity, 43.5% positive predictive value and 100% negative predictive value.
Conclusions: AHF persists as a frequent complication in individuals with anterior STEMI who are treated with pPCI. Delay in primary angioplasty for patients with STEMI has significant prognostic implications, as shown by the present research. Total ischemia time must be reduced to increase survival in individuals with ST-elevation myocardial infarction (STEMI).
 

Pages: 40-45  |  249 Views  74 Downloads


International Journal of Cardiology Sciences
How to cite this article:
Eman Helmy Eldesokey, Medhat Mohamed Ashmawy, Mohamed Naseem Hussien, Amany Mohammed AL-Laithy. Impact of the time factor on the development of in-hospital heart failure in patients presenting with anterior ST-segment elevation myocardial infarction undergoing primary PCI. Int. J. Cardiol. Sci. 2023;5(2):40-45. DOI: 10.33545/26649020.2023.v5.i2a.37