Vol. 5, Issue 1, Part A (2023)

Background: As indicators for systemic inflammation, elevated C-reactive protein (CRP) and reduced albumin levels were demonstrated to be predictive of unfavourable cardiovascular events) CV(events. Moreover, it was proposed that the new Ratio between CRP and Albumin (CAR) was more sensitive and selective for assessing the systemic inflammatory status in non-cardiac illnesses than the predictive value of these 2 indicators independently. The purpose of this study was to assess the relationship between the ratio of CAR and coronary thrombus load in individuals with acute myocardial infarction (AMI).
Methods: This prospective cross-sectional study was carried out 100 patients with STEMI undergoing primary PCI and Patients with Non-STEMI undergoing for coronary angiography as soon as possible. Patients were divided into 2 groups: low thrombus load (grades 1-2) and high-thrombus load (grades 3 and 4). All patients underwent full history taking, complete clinical examination, standard 12-leads ECG, resting trans-thoracic echocardiography (TTE), laboratory investigations: including troponin I or T, serum albumin, serum CRP and other routine laboratory tests including serum creatinine, hemoglobin level and total lipid profile, CAR. 
Results: CRP was significantly higher in the high thrombus load (p =0.03) and albumin was significantly higher in low thrombus load (p =0.004). CAR was significantly higher in the high thrombus load (p =0.02). A significant positive correlation was found between CRP, CAR and NLR and thrombus load grade (P =0.017, <0.001 respectively) and a significant negative correlation was found between albumin and thrombus load grade (p =0.007). In univariate regression analysis, CRP Albumin and CAR were significant predictor for thrombus while NLR was insignificant predictor for thrombus
Conclusions: The level of CRP, Alb and CAR also increased troponin level is considered as a good predictor for myocardial infarction.